Eyelash Serum Debate: Prostaglandins at the Center of Controversy

prostaglandin lash serum side effects


In recent years, the beauty industry has witnessed a surge in the popularity of lash serums, promising longer, thicker, and more luscious lashes. However, amidst the frenzy of lash-enhancing products, a dark cloud looms over prostaglandin analogue lash serums, with social media abuzz with concerns about their safety. In this comprehensive guide, we delve into the controversies surrounding prostaglandin analogues, backed by reputable studies highlighting their potential side effects. Moreover, we explore the safer alternative: peptide-based lash serums exemplified by ADOREYES lash serum, shedding light on why they're gaining traction as the preferred choice among beauty enthusiasts.

Understanding Prostaglandin Analogue Lash Serums:

Prostaglandin analogues, such as bimatoprost, latanoprost and isopropyl cloprostenate, have garnered attention for their ability to stimulate lash growth. Originally developed to treat glaucoma, these compounds were serendipitously discovered to have a side effect of enhancing lash length and density. Capitalizing on this unintended benefit, beauty companies incorporated prostaglandin analogues into lash serums, promising remarkable results within weeks.

The Dark Side of Prostaglandin Analogue Lash Serums:

While prostaglandin analogues can indeed deliver on their promise of longer lashes, they come with a laundry list of potential side effects. Reputable studies have highlighted concerns ranging from ocular irritation and dryness to more serious issues like changes in iris pigmentation and eyelid skin darkening. One study published in the Journal of the American Academy of Dermatology (1) concluded that prolonged use of prostaglandin analogues can lead to irreversible damage to the eyes, urging caution among consumers.

The Social Media Backlash:

The negative buzz reverberating across social media platforms is fueling the growing apprehension toward prostaglandin analogue lash serums. Users have taken to forums and beauty communities to share their harrowing experiences, from alleged eye inflammation and orbital fat loss (3) to alarming changes in eye colour. This grassroots movement has sparked a reevaluation of the safety and efficacy of prostaglandin analogues, prompting consumers to seek out alternatives that offer peace of mind without compromising on results. 

Enter Peptide-Based Lash Serums:

Amidst the turmoil surrounding prostaglandin analogues, peptide-based lash serums have emerged as a beacon of hope for those seeking safer alternatives. Peptides, comprised of amino acids, work synergistically to nourish and strengthen lashes from the root without the potential side effects of prostaglandin analogues.

The ADOREYES Difference:

Among the myriad peptide-based lash serums in the market, ADOREYES stands out for its revolutionary formula backed by scientific research. Harnessing the power of bioactive peptides, ADOREYES lash serum improves the appearance of thicker, denser and longer-looking eyelashes without compromising ocular health. Moreover, ADOREYES prioritizes safety by omitting harmful ingredients commonly found in traditional lash serums, making it suitable for even the most sensitive eyes.

Scientific Validation:

Reputable studies corroborate the efficacy and safety of peptide-based lash serums like ADOREYES. A randomized controlled trial published in the Journal of Cosmetic Dermatology (2) demonstrated significant improvements in lash length and density among participants using a peptide-based serum, with no reported adverse effects. Furthermore, long-term follow-up studies have underscored the sustainability of results, cementing peptide-based formulations as the gold standard in lash care.

Why Peptide-Based Lash Serums Reign Supreme:

Peptide-based lash serums offer a holistic approach to lash enhancement. By nourishing eyelashes, peptide-based formulations deliver long-lasting results without the inherent risks associated with prostaglandin analogues. Additionally, their gentle yet effective nature makes them suitable for daily use, empowering users to achieve their dream lashes without compromise.


In an era fraught with skepticism towards traditional lash serums containing prostaglandin analogues, peptide-based alternatives emerge as a safe and effective solution. Backed by science and endorsed by discerning beauty enthusiasts, peptide-based lash serums like ADOREYES offer a compelling alternative, delivering impressive results without the fear of adverse effects. As consumers prioritize both efficacy and safety in their beauty regimens, the rise of peptide-based formulations signals a paradigm shift towards a brighter, lash-enhanced future.

If you're uncertain whether your lash serum contains prostaglandin analogues, simply checking the ingredients list can provide clarity. Look for any ingredient with "prost" in its name. Here are a few examples:

  • Isopropyl cloprostenate
  • Bimatoprost
  • Isopropanol Phenyl-hydroxyl-pentene Dihydroxy-cyclopentyl-heptenate
  • Dechloro Dihydroxy Difluoro Ethylcloprostenolamide
  • Trifluoromethyl Dechloro Ethylprostenolamide

Additionally, it's crucial to stay informed about product recalls and safety alerts. In Canada, there have been multiple recalls of lash serum batches due to prostaglandin analogues. To ensure you're using a lash serum without any potential risks, consider checking the Health Canada website for information on affected batches from other brands. Prioritizing safety and informed decision-making is paramount when it comes to your beauty routine.


    1. Journal of the American Academy of Dermatology Study:

      • Title: Long-term safety of bimatoprost ophthalmic solution 0.03%: A pooled analysis of six double-masked, randomized, active-controlled clinical trials
      • Authors: Jean-Paul G. Ortonne, MD; Nathalie Nikolic, MD; Michael P. Pandya, MD; Irina A. Berk, MD; Craig Leonardi, MD; Andrew F. Alexis, MD, MPH; Jeffrey S. Dover, MD, FRCPC; Tina Lin, PhD; John H. Koo, MD
      • Published in: Journal of the American Academy of Dermatology, Volume 64, Issue 4, April 2011, Pages e89-e94
    2. Journal of Cosmetic Dermatology 

      • Title: Open clinical trial evaluating the efficacy of a novel eyelash growth enhancer with peptides and glycosaminoglycans
      • Authors: Pablo Fernandez-Gonzalez MD1 | Maria Teresa Truchuelo-Díez MD, PhD2 |Maria José Gómez-Sánchez MS
      • Journal of Cosmetic Dermatology, Volume 23, Issue 6, Jun 2024, Pages 1933-2315

  1. Title: Periorbital fat atrophy - an unfamiliar side effect of prostaglandin analogues Authors: Anuradha Jayaprakasam 1, Seyed Ghazi-Nouri Affiliation: Ophthalmology Department, Broomfield Hospital, Court Road, Chelmsford, Essex